Article
Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study.
Pharmacogenetics and genomics - 1 Nov 2006
Motsinger Alison A, Ritchie Marylyn D, Shafer Robert W, Robbins Gregory K, Morse Gene D, Labbe Line, Wilkinson Grant R, Clifford David B, D'Aquila Richard T, Johnson Victoria A, Pollard Richard B, Merigan Thomas C, Hirsch Martin S, Donahue John P, Kim Richard B, Haas David W
Abstract excerpt
OBJECTIVE: For the HIV-1 reverse transcriptase inhibitor efavirenz, variant drug transporter gene ABCB1 may predict virologic response but not plasma efavirenz exposure. Conversely, variant drug metabolizing enzyme gene CYP2B6 predicts greater plasma efavirenz exposure but not virologic response. We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.