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Gene Bionetwork Analysis of Ovarian Primordial Follicle Development

16 Jul 2010

Abstract excerpt

Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth factors known to influence primordial follicles were used to construct a bionetwork of regulatory genes involved in...

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PMID: 20661288
DOI: 10.1371/journal.pone.0011637

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