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A Single-Cell Omics Network Model of Cell Crosstalk during the Formation of Primordial Follicles

20 Jan 2022

Abstract excerpt

The fate of fetal germ cells (FGCs) in primordial follicles is largely determined by how they interact with the surrounding granulosa cells. However, the molecular mechanisms underlying this interactive process remain poorly understood. Here, we develop a computational model to characterize how individual genes program and rewire cellular crosstalk across FGCs and somas, how gene regulatory networks mediate...

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PMID: 35159142
DOI: 10.3390/cells11030332

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