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Article

Novel missense and truncating mutations in <i>FUS/TLS</i> in familial ALS

22 Jul 2010

Abstract excerpt

BACKGROUND: Mutations in the FUS/TLS gene have been associated with familial amyotrophic lateral sclerosis (FALS). METHODS: We analyzed the presence and frequency of C-terminal FUS/TLS mutations in a German amyotrophic lateral sclerosis (ALS) cohort, including 133 patients with sporadic ALS (SALS) and 58 patients with FALS by sequence analysis of exons 13-15. RESULTS: We identified 2 novel heterozygous FUS/TLS...

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PMID: 20660363
DOI: 10.1212/wnl.0b013e3181f07e26

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