Article
Mutations in FUS cause FALS and SALS in French and French Canadian populations.
Neurology - 13 Oct 2009
Belzil V V, Valdmanis P N, Dion P A, Daoud H, Kabashi E, Noreau A, Gauthier J, Hince P, Desjarlais A, Bouchard J-P, Lacomblez L, Salachas F, Pradat P-F, Camu W, Meininger V, Dupré N, Rouleau G A
Abstract excerpt
BACKGROUND: The identification of mutations in the TARDBP and more recently the identification of mutations in the FUS gene as the cause of amyotrophic lateral sclerosis (ALS) is providing the field with new insight about the mechanisms involved in this severe neurodegenerative disease. METHODS: To extend these recent genetic reports, we screened the entire gene in a cohort of 200 patients with ALS. An additional...
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