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Article

Genetic contribution of <i>FUS</i> to frontotemporal lobar degeneration

1 Feb 2010

Abstract excerpt

BACKGROUND: Recently, the FUS gene was identified as a new causal gene for amyotrophic lateral sclerosis (ALS) in approximately 4% of patients with familial ALS. Since ALS and frontotemporal lobar degeneration (FTLD) are part of a clinical, pathologic, and genetic disease spectrum, we investigated a potential role of FUS in FTLD. METHODS: We performed mutational analysis of FUS in 122 patients with FTLD and 15...

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PMID: 20124201
DOI: 10.1212/wnl.0b013e3181ccc732

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