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Erythropoietin Receptor Signaling through STAT3 Is Required for Glioma Stem Cell Maintenance

1 Jan 2010

Abstract excerpt

Recombinant erythropoietin (EPO) is a growth factor used in the treatment of chemotherapy-induced anemia, but recent studies suggest that EPO may accelerate cancer growth. Although several cancers express EPO receptors (EPORs), the mechanism by which EPOR promotes tumor growth remains poorly understood. Glioblastomas display a cellular hierarchy of self-renewal and tumor propagation restricted to glioma stem...

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PMID: 20657792
DOI: 10.1177/1947601909356352

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