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Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence <i>In situ</i> Hybridization–Based Case-Control Study

22 Jul 2010

Abstract excerpt

PURPOSE: We performed a study to determine if a fluorescence in situ hybridization (FISH)-based assay using isolated peripheral blood mononuclear cells (PBMCs) with DNA probes targeting specific sites on chromosomes known to have abnormalities in non-small cell lung cancer (NSCLC) cases could detect circulating genetically abnormal cells (CACs). EXPERIMENTAL DESIGN: We evaluated 59 NSCLC cases with stage I...

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PMID: 20651054
DOI: 10.1158/1078-0432.ccr-09-3358

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