Article
The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Tenkanen H, Lukka M, Jauhiainen M, Metso J, Baumann M, Peltonen L, Ehnholm C
Abstract excerpt
Apolipoprotein (apo) A-IV is a protein involved in the metabolism of chylomicrons and high density lipoproteins. This protein displays genetic polymorphism due to two main codominant alleles, A-IV1 and A-IV2. We have identified the mutation that leads to this polymorphism. It is caused by a single-base substitution of guanine for thymine in the third base of codon 360. This substitution leads to a glutamine to...
Topics
- Amino Acid Sequence
- Apolipoproteins A
- Base Sequence
- DNA Mutational Analysis
- Enzyme Activation
- Genotype
- Glutamine
- Guanine Nucleotides
- Histidine
- Humans
- Isoelectric Focusing