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Article

Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.

BMC evolutionary biology - 22 Jul 2010

Koyanagi Madoka, Kerns Julie A, Chung Linda, Zhang Yan, Brown Scott, Moldoveanu Tudor, Malik Harmit S, Bix Mark

Abstract excerpt

BACKGROUND: Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths 1. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we explored mammalian IL4 evolution. RESULTS: This analysis revealed evidence of diversifying selection at 15 residues, clustered in epitopes responsible for IL4 binding to its...

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Identifiers

PMID: 20649995
DOI: 10.1186/1471-2148-10-223
PMCID: PMC3017759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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