Article
An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Ohigashi Yuki, Ma Chunlong, Jing Xianghong, Balannick Victoria, Pinto Lawrence H, Lamb Robert A
Abstract excerpt
Influenza A virus M2 (A/M2) and the influenza B virus BM2 are both small integral membrane proteins that form proton-selective ion channels. Influenza A virus A/M2 channel is the target of the antiviral drug amantadine (and its methyl derivative rimantadine), whereas BM2 channel activity is not affected by the drug. The atomic structure of the pore-transmembrane (TM) domain peptide has been determined by x-ray...
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