Therapeutic potential of a synthetic lethal interaction between the <i>MYC</i> proto-oncogene and inhibition of aurora-B kinase

Abstract excerpt

The Myc protein and proteins that participate in mitosis represent attractive targets for cancer therapy. However, their potential is presently compromised by the threat of side effects and by a lack of pharmacological inhibitors of Myc. Here we report that a circumscribed exposure to the aurora kinase inhibitor, VX-680, selectively kills cells that overexpress Myc. This synthetic lethal interaction is...

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