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Article

Is prophylactic colectomy indicated in patients with MYH-associated polyposis?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Jul 2005

Leite J S, Isidro G, Martins M, Regateiro F, Albuquerque O, Amaro P, Romãozinho J M, Boavida G, Castro-Sousa F

Abstract excerpt

OBJECTIVES: The MYH gene has recently been associated with multiple colorectal tumours. It participates in the DNA base-excision-repair, avoiding mutations in other genes, namely the APC and Ki-ras. Recently, biallelic MYH mutations have been described in patients with attenuated polyposis and in 7.5% with classic polyposis and no detectable APC mutation. The aim of this study was to analyse the incidence of...

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Source

Identifiers

PMID: 15932553
DOI: 10.1111/j.1463-1318.2005.00811.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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