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Article

Locus category based analysis of a large genome-wide association study of rheumatoid arthritis.

Human molecular genetics - 1 Oct 2010

Freudenberg Jan, Lee Annette T, Siminovitch Katherine A, Amos Christopher I, Ballard David, Li Wentian, Gregersen Peter K

Abstract excerpt

To pinpoint true positive single-nucleotide polymorphism (SNP) associations in a genome-wide association study (GWAS) of rheumatoid arthritis (RA), we categorize genetic loci by external knowledge. We test both the 'enrichment of associated loci' in a locus category and the 'combined association' of a locus category. The former is quantified by the odds ratio for the presence of SNP associations at the loci of a...

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Identifiers

PMID: 20639398
DOI: 10.1093/hmg/ddq304
PMCID: PMC2935861

Genes

MBL2
TEC
TXK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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