Article
The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: a possible impact on the natural history of the disease.
Biochimica et biophysica acta - 1 Jan 2011
Marchesi Marta, Parolini Cinzia, Valetti Caterina, Mangione Palma, Obici Laura, Giorgetti Sofia, Raimondi Sara, Donadei Simona, Gregorini Gina, Merlini Giampaolo, Stoppini Monica, Chiesa Giulia, Bellotti Vittorio
Abstract excerpt
Hereditary systemic amyloidosis caused by apolipoprotein A-I variants is a dominantly inherited disease characterised by fibrillar deposits mainly localized in the kidneys, liver, testis and heart. We have previously shown that the apolipoprotein A-I variant circulates in plasma at lower levels t...
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