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Article

Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell.

The EMBO journal - 16 May 2007

Sato Takashi, Susuki Seiko, Suico Mary Ann, Miyata Masanori, Ando Yukio, Mizuguchi Mineyuki, Takeuchi Makoto, Dobashi Mizuki, Shuto Tsuyoshi, Kai Hirofumi

Abstract excerpt

The secretion of transthyretin (TTR) variants contributes to the pathogenesis of amyloidosis because they form aggregates in the extracellular environment. However, the mechanism of how TTR variants pass the quality control system in the endoplasmic reticulum (ER) has not yet been elucidated. We investigated here the mechanism of how TTR passes ER monitoring. Monomeric mutation introduced in TTRs (M-TTRs)...

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Source

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Identifiers

PMID: 17431395
DOI: 10.1038/sj.emboj.7601685
PMCID: PMC1868898

Genes

TTR
GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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