Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary framework for protein sequence evolution and gene pleiotropy.

Genetics - 1 Apr 2007

Gu Xun

Abstract excerpt

In this article, we develop an evolutionary model for protein sequence evolution. Gene pleiotropy is characterized by K distinct but correlated components (molecular phenotypes) that affect the organismal fitness. These K molecular phenotypes are under stabilizing selection with microadaptation (SM) due to random optima shifts, the SM model. Random coding mutations generate a correlated distribution of K...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Evolution, Molecular
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Phylogeny

Share to Proteins

Share to Selection, Genetic

Share to Vertebrates

Source

Open in PubMed Open full text

Identifiers

PMID: 17277368
DOI: 10.1534/genetics.106.066530
PMCID: PMC1855142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary framework for protein sequence evolution and gene pleiotropy.PMID 17277368Read ↗

Molecular evolution, mutation size and gene pleiotropy: a geometric reexamination.Semantic proximity Read ↗

A preliminary analysis of gene pleiotropy estimated from protein sequences.Semantic proximity Read ↗

Model parameters of molecular evolution explain genomic correlations.Semantic proximity Read ↗

Pleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.Semantic proximity Read ↗

Determining the factors driving selective effects of new nonsynonymous mutations.Semantic proximity Read ↗

Scaling of mutational effects in models for pleiotropy.Semantic proximity Read ↗

Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory.Semantic proximity Read ↗

Gene functional trade-offs and the evolution of pleiotropy.Semantic proximity Read ↗

A pleiotropic model of phenotypic evolution.Semantic proximity Read ↗

Aligning functional network constraint to evolutionary outcomesSemantic proximity Read ↗

Fisher's model and the genomics of adaptation: restricted pleiotropy, heterogenous mutation, and parallel evolution.Semantic proximity Read ↗

Causes of molecular convergence and parallelism in protein evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.