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Article

Involvement of threonine 258 and serine 259 motif in amphetamine-induced norepinephrine transporter endocytosis.

Journal of neurochemistry - 1 Oct 2010

Annamalai Balasubramaniam, Mannangatti Padmanabhan, Arapulisamy Obulakshmi, Ramamoorthy Sammanda, Jayanthi Lankupalle D

Abstract excerpt

D-amphetamine (AMPH) down-regulates the norepinephrine transporter (NET), although the exact trafficking pathways altered and motifs involved are not known. Therefore, we examined the cellular and molecular mechanisms involved in AMPH-induced NET regulation in human placental trophoblast cells expressing the wild-type (WT)-hNET and the hNET double mutant (DM)-bearing protein kinase C (PKC)-resistant T258A + S259A...

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Identifiers

PMID: 20626559
DOI: 10.1111/j.1471-4159.2010.06898.x
PMCID: PMC2939970

Genes

AMPH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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