Article
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
The Journal of infectious diseases - 15 Aug 2010
Sezgin Efe, Jabs Douglas A, Hendrickson Sher L, Van Natta Mark, Zdanov Alexander, Lewis Richard Alan, Smith Michael W, Troyer Jennifer L, O'Brien Stephen J
Abstract excerpt
BACKGROUND: Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression...
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