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Infection with flaviviruses requires BCLXL for cell survival

27 Sept 2018

Abstract excerpt

BCL2 family proteins including pro-survival proteins, BH3-only proteins and BAX/BAK proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. In this study, we examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus....

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PMID: 30261081
DOI: 10.1371/journal.ppat.1007299

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