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Article

MicroRNA-146: Tiny Player in Neonatal Innate Immunity?

9 Jul 2010

Abstract excerpt

BACKGROUND: Concise regulation of the Toll signaling pathway is mandatory in neonatal innate immunity. The microRNA-146 family (miR-146a/b) was recently reported to be a regulator of Toll-like receptor 4 (TLR4) through a negative feedback loop mechanism. Acting as a potent regulator, miRNA helps to protect the organism from developing overwhelming proinflammatory immune responses leading to septic shock or...

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PMID: 20616571
DOI: 10.1159/000301938

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