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Article

Uracil DNA glycosylase: revisiting substrate-assisted catalysis by DNA phosphate anions.

Biochemistry - 19 Aug 2008

Parker Jared B, Stivers James T

Abstract excerpt

Uracil DNA glycosylase (UNG) is a powerful DNA repair enzyme that has been shown to stabilize a glycosyl cation reaction intermediate and a related tight binding inhibitor using electrostatic interactions with the +1 and -1, but not the +2, phosphodiester group of the single-stranded DNA substrate Ap (2+)Ap (1+)Up (1-)ApA. These experimental results differed considerably from computational findings using duplex...

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Identifiers

PMID: 18652484
DOI: 10.1021/bi800854g
PMCID: PMC2729715

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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