Article
Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Oct 2010
Lee Kyu Young, Song Joo Yun, Kim Se Hyun, Kim Seong Chan, Joo Eun-Jeong, Ahn Yong Min, Kim Yong Sik
Abstract excerpt
Genes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder. A single nucleotide polymorphism (SNP) in the 3'-flanking region of CLOCK (3111T/C; rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar...
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