Article
The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Feb 2005
Mishima Kazuo, Tozawa Takuma, Satoh Kohtoku, Saitoh Hidetomo, Mishima Yumiko
Abstract excerpt
Sleep timing is influenced by the circadian system. Morningness-eveningness (ME) preference in humans is affected by the free-running period, which is determined by circadian clock-relevant genes. In this study, we investigated association between the 3111T/C polymorphism in the 3'-flanking region of hClock (Homo sapiens Clock homolog) and ME preference in 421 Japanese subjects. The Horne-Ostberg ME questionnaire...
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