Article
Thermodynamics of antiparallel hairpin-double helix equilibria in DNA oligonucleotides from equilibrium ultracentrifugation.
Biochemistry - 25 Jun 1991
Ross P D, Howard F B, Lewis M S
Abstract excerpt
Five highly palindromic DNA dodecamers, four of which may form G-A or I-A purine-purine mispairs at either the 5.8 or 6.7 positions, have been studied at sedimentation equilibrium in the analytical ultracentrifuge. Each DNA oligonucleotide forms an equilibrium mixture of ordered antiparallel hairpin and double-stranded helical structures in solutions of 0.1 or 0.5 M NaCl between 5 and 40 degrees C. The dimeric...
Topics
- Base Sequence
- DNA
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleic Acid Heteroduplexes
- Oligonucleotides
- Thermodynamics
- Ultracentrifugation