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Article

Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.

The Journal of biological chemistry - 3 Sept 2010

Jeon Young Jin, Lee Kun Yeong, Cho Yong-Yeon, Pugliese Angelo, Kim Hong Gyum, Jeong Chul-Ho, Bode Ann M, Dong Zigang

Abstract excerpt

NEK6 (NIMA-related kinase 6) is a homologue of the Aspergillus nidulans protein NIMA (never in mitosis, gene A). We demonstrate that overexpression of NEK6 induces anchorage-independent transformation of JB6 Cl41 mouse epidermal cells. Tissue arrays and Western immunoblot analysis show that NEK6 is overexpressed in malignant tissues and several cancer cell lines. Our data also show that NEK6 interacts with STAT3,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20595392
DOI: 10.1074/jbc.M110.137190
PMCID: PMC2934677

Genes

NEK6
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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