Article
A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.
European heart journal - 1 Feb 2011
Versmissen Jorie, Oosterveer Daniëlla M, Yazdanpanah Mojgan, Mulder Monique, Dehghan Abbas, Defesche Joep C, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
AIMS: Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present aim was to test if the ABCA1 C69T polymorphism influences CHD risk and response to statin...
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