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Article

Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability.

PloS one - 25 Jun 2010

Li Qingxue, Ali Mir A, Wang Kening, Sayre Dean, Hamel Frederick G, Fischer Elizabeth R, Bennett Robert G, Cohen Jeffrey I

Abstract excerpt

Varicella-zoster virus (VZV) glycoprotein E (gE) is essential for virus infectivity and binds to a cellular receptor, insulin-degrading enzyme (IDE), through its unique amino terminal extracellular domain. Previous work has shown IDE plays an important role in VZV infection and virus cell-to-cell spread, which is the sole route for VZV spread in vitro. Here we report that a recombinant soluble IDE (rIDE) enhances...

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Identifiers

PMID: 20593027
DOI: 10.1371/journal.pone.0011327
PMCID: PMC2892511

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IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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