Article
Open reading frame S/L of varicella-zoster virus encodes a cytoplasmic protein expressed in infected cells.
Journal of virology - 1 Dec 2000
Kemble G W, Annunziato P, Lungu O, Winter R E, Cha T A, Silverstein S J, Spaete R R
Abstract excerpt
We report the discovery of a novel gene in the varicella-zoster virus (VZV) genome, designated open reading frame (ORF) S/L. This gene, located at the left end of the prototype VZV genome isomer, expresses a polyadenylated mRNA containing a splice within the 3' untranslated region in virus-infected cells. Sequence analysis reveals significant differences between the ORF S/Ls of wild-type and attenuated strains of...
Topics
- Adult
- Amino Acid Sequence
- Animals
- Base Sequence
- Chlorocebus aethiops
- Cytoplasm
- Ganglia, Spinal
- Genome, Viral
- Herpesvirus 3, Human
- Humans
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- RNA, Viral