Article
TP53 gene mutations in prostate cancer progression.
Anticancer research - 1 May 2010
Ecke Thorsten H, Schlechte Horst H, Schiemenz Katrin, Sachs Markus D, Lenk Severin V, Rudolph Birgit D, Loening Stefan A
Abstract excerpt
BACKGROUND: We assessed the predictive value of TP53 mutations and prostate-specific antigen (PSA) for tumor progression in prostate cancer (PCa) patients. MATERIALS AND METHODS: Ninety tumor tissue samples of patients with PCa from radical prostatectomy were used. Tumor progression was estimated biochemically by the PSA level (> 0.2 microg/l) or by detection of metastases. Screening for TP53 mutations was...
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