Article
Role of functional polymorphisms of P53 and P73 genes with the risk of prostate cancer in a case-control study from Northern India.
Archives of medical research - 1 Feb 2011
Mittal Rama Devi, George Ginu P, Mishra Jyotsna, Mittal Tulika, Kapoor Rakesh
Abstract excerpt
BACKGROUND AND AIMS: P53 gene variants BstUI RFLP at codon 72 in exon 4, 16-bp tandem repeat in intron 3 and Msp I RFLP in intron 6 and P73 gene variants of G4C14-to-A4T14 (GC/AT), exon 2 polymorphism, which respectively codes for four functionally different protein isoforms, have been shown to modulate susceptibility to different types of human neoplasms. We undertook this study to evaluate the role of P53 and...
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