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Article

Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.

Genetics - 1 Sept 2010

Ambegaokar Surendra S, Jackson George R

Abstract excerpt

Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at...

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Identifiers

PMID: 20592261
DOI: 10.1534/genetics.110.119545
PMCID: PMC2940309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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