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Article

Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entity

2 Dec 2021

Abstract excerpt

Neutrophil homeostasis results from a balance between neutrophil production, release from the bone marrow and clearance from the circulation, where chemokines and their receptors play central roles. tudies on mice demonstrated that CXCR4 and CXCR2 receptors antagonistically regulate bone marrow neutrophil release. 2 While CXCR4 and its chemokine CXCL12, which is constitutively expressed in the bone marrow,...

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Identifiers

PMID: 34854278
DOI: 10.3324/haematol.2021.279254

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