Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma.

doi:10.1016/j.biopsych.2010.05.008

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Article

Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma.

Biological psychiatry - 1 Sept 2010

van IJzendoorn Marinus H, Caspers Kristin, Bakermans-Kranenburg Marian J, Beach Steven R H, Philibert Robert

Abstract excerpt

BACKGROUND: Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences? METHODS: DNA was obtained from growth phase entrained Epstein-Barr Virus (EBV) transformed lymphoblast cell lines from 143 adopted participants. Genotype of the serotonin transporter linked polymorphic region (5HTTLPR) was determined, and...

Topics

Adoption
Cell Line, Transformed
CpG Islands
DNA Methylation
Epigenesis, Genetic
Female
Genetic Association Studies
Genetic Predisposition to Disease
Herpesvirus 4, Human
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Interview, Psychological

Male

Polymorphism, Genetic

Serotonin Plasma Membrane Transport Proteins

Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 20591416
DOI: 10.1016/j.biopsych.2010.05.008
PMCID: PMC2921470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20591416-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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