Article
Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2010
Fairbridge Nicholas A, Dawe Christine E, Niri Farshad H, Kooistra Megan K, King-Jones Kirst, McDermid Heather E
Abstract excerpt
BACKGROUND: Over 200 mouse genes are associated with neural tube defects (NTDs), including Cecr2, the bromodomain-containing subunit of the CERF chromatin remodeling complex. METHODS: Gene-trap mutation Cecr2(Gt45Bic) results in 74% exencephaly (equivalent of human anencephaly) on the BALB/c strain. Gene expression altered during cranial neural tube closure by the Cecr2 mutation was identified through microarray...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.