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Article

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

11 Nov 2008

Abstract excerpt

BACKGROUND: The tumor suppressor p53 is an important regulator that controls various cellular networks, including cell differentiation. Interestingly, some studies suggest that p53 facilitates cell differentiation, whereas others claim that it suppresses differentiation. Therefore, it is critical to evaluate whether this inconsistency represents an authentic differential p53 activity manifested in the various...

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PMID: 19002260
DOI: 10.1371/journal.pone.0003707

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