Article
Neuroendocrine evidence of normal hypothalamus-pituitary dopaminergic function in Huntington's disease.
Neuro endocrinology letters - 1 Jan 2010
Markianos Manolis, Panas Marios, Kalfakis Nikos, Hatzimanolis John, Vassilopoulos Dimitrios
Abstract excerpt
OBJECTIVES: In addition to neuronal loss in striatum and cerebral cortex that characterizes Huntington's disease (HD), hypothalamic atrophy has also been found only in certain areas, probably not including dopaminergic functions. METHODS: We assessed the reactivity of the hypothalamus-pituitary dopaminergic system by measuring the acute prolactin (PRL) responses to 5 mg i.m. haloperidol in male and female HD...
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