Article
Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys.
PLoS genetics - 24 Jun 2010
Lim So-Yon, Chan Tiffany, Gelman Rebecca S, Whitney James B, O'Brien Kara L, Barouch Dan H, Goldstein David B, Haynes Barton F, Letvin Norman L
Abstract excerpt
CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 acquisition and with both viral load and disease progression following infection with HIV-1. An association has also been reported between CCL3L CNV and clinical sequelae of the simian...
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