Article
HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner.
Blood - 15 Apr 2005
Scortegagna Marzia, Ding Kan, Zhang Quiyang, Oktay Yavuz, Bennett Michael J, Bennett Michael, Shelton John M, Richardson James A, Moe Orson, Garcia Joseph A
Abstract excerpt
Erythropoiesis in the adult mammal depends critically on erythropoietin, an inducible cytokine with pluripotent effects. Erythropoietin gene expression increases under conditions associated with lowered oxygen content such as anemia and hypoxia. HIF-1alpha, the founding member of the hypoxia-inducible factor (HIF) alpha class, was identified by its ability to bind and activate the hypoxia-responsive enhancer in...
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