Article
The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.
The Journal of experimental medicine - 5 Jul 2010
Zhang Min, Fennell Clare, Ranford-Cartwright Lisa, Sakthivel Ramanavelan, Gueirard Pascale, Meister Stephan, Caspi Anat, Doerig Christian, Nussenzweig Ruth S, Tuteja Renu, Sullivan William J, Roos David S, Fontoura Beatriz M A, Ménard Robert, Winzeler Elizabeth A, Nussenzweig Victor
Abstract excerpt
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active process controlled by a eukaryotic initiation factor-2alpha (eIF2alpha) kinase (IK2) and a phosphatase. IK2 activity is dominant in salivary gland sporozoites,...
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