Article
Cross-linking of ΔF508-CFTR promotes its trafficking to the plasma membrane.
Channels (Austin, Tex.) - 1 Jan 2000
Bernard Karen, Kirk Kevin L
Abstract excerpt
CFTR is a cAMP-activated chloride channel responsible for agonist stimulated chloride and fluid transport across epithelial surfaces.(1) Mutations in the CFTR gene lead to cystic fibrosis (CF) which affects the function of secretory organs like the intestine, the pancreas, the airways and the sweat glands. Most of the morbidity and mortality in CF has been linked to a decrease in airway function.(2) The ΔF508...
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