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Article

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

Trends in molecular medicine - 1 Feb 2012

Lukacs Gergely L, Verkman A S

Abstract excerpt

Cystic fibrosis (CF), the most common lethal genetic disease in the Caucasian population, is caused by loss-of-function mutations of the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated plasma membrane chloride channel. The most common mutation, deletion of phenylalanine 508 (ΔF508), impairs CFTR folding and, consequently, its biosynthetic and endocytic processing as well as chloride channel...

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Identifiers

PMID: 22138491
DOI: 10.1016/j.molmed.2011.10.003
PMCID: PMC3643519

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Therapeutic approaches to CFTR dysfunction: From discovery to drug development.Semantic proximity Read ↗

Altered protein folding may be the molecular basis of most cases of cystic fibrosisSemantic proximity Read ↗

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