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Article

GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors.

Brain research - 30 Jul 2010

Eshaq Randa S, Stahl Letha D, Stone Randolph, Smith Sheryl S, Robinson Lucy C, Leidenheimer Nancy J

Abstract excerpt

GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in brain. The fast inhibitory effect of GABA is mediated through the GABA(A) receptor, a postsynaptic ligand-gated chloride channel. We propose that GABA can act as a ligand chaperone in the early secretory pathway to facilitate GABA(A) receptor cell surface expression. Forty-two hours of GABA treatment increased the surface expression of...

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Identifiers

PMID: 20580636
DOI: 10.1016/j.brainres.2010.05.030
PMCID: PMC2941995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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