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Article

Male CD81 knockout genotype disrupts Mendelian distribution of offspring.

Comparative medicine - 1 Jun 2010

Mordica Whitney J, Gallagher Ryan J, Kennedy Jenna L, Chapes Stephen K

Abstract excerpt

CD81 is an integral membrane protein in the tetraspanin superfamily that serves as an adaptor protein. CD81 is also a maternally imprinted gene that is found in a regulated cluster of genes on mouse chromosome 7. Among offspring produced from heterozygous breeding pairs, CD81(null/null) mice grew at the same rate as CD81(+/+) and CD81(+/null) mice. Because of an inhibition in sperm-egg fusion, CD81(null/null)...

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Identifiers

PMID: 20579434
PMCID: PMC2890394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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