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Article

Down-Regulated MicroRNA-152 Induces Aberrant DNA Methylation in Hepatitis B Virus–Related Hepatocellular Carcinoma by Targeting DNA Methyltransferase 1

15 Mar 2010

Abstract excerpt

UNLABELLED: The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying mechanisms remain unknown. MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are involved in diverse biological functions and in carcinogenesis. In this study, we investigated whether some miRNAs are...

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PMID: 20578129
DOI: 10.1002/hep.23660

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