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Article

Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression.

Depression and anxiety - 1 Aug 2010

Conway Christopher C, Hammen Constance, Brennan Patricia A, Lind Penelope A, Najman Jake M

Abstract excerpt

BACKGROUND: Investigations of gene-environment interaction (GxE) in depression have implicated a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-depression relationship. However, recent evidence for 5-HTTLPR GxE in depression has been...

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PMID: 20577990
DOI: 10.1002/da.20715
PMCID: PMC2918677

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20577990-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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