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Article

XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia.

American journal of hematology - 1 Jul 2010

Guillem Vicent M, Cervantes Francisco, Martínez Jesús, Alvarez-Larrán Alberto, Collado María, Camós Mireia, Sureda Anna, Maffioli Margherita, Marugán Isabel, Hernández-Boluda Juan-Carlos

Abstract excerpt

Chronic myeloid leukemia (CML) is driven by the BCR-ABL protein, which promotes the proliferation and viability of the leukemic cells. Moreover, BCR-ABL induces genomic instability that can contribute to the emergence of resistant clones to the ABL kinase inhibitors. It is currently unknown whether the inherited individual capability to repair DNA damage could affect the treatment results. To address this, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20575039
DOI: 10.1002/ajh.21726

Genes

XPC
BCR
ERCC2
ERCC5
ERCC8
LIG1
RPA1
RPA3
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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