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Article

CXCR4 gene transfer contributes to in vivo reendothelialization capacity of endothelial progenitor cells

23 Jun 2010

Abstract excerpt

AIMS: Endothelial progenitor cells (EPCs) play a pivotal role in endothelial repair after artery injury. The chemokine receptor CXCR4 is a key modulator of the homing of EPCs to impaired artery and reendothelialization. In this study, we addressed the hypothesis that CXCR4 gene transfer could enhance the reendothelialization capacity of EPCs. METHODS AND RESULTS: In vitro, human EPCs were expanded and transduced...

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PMID: 20573729
DOI: 10.1093/cvr/cvq207

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