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Article

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

Brain : a journal of neurology - 1 Jul 2010

Chung Chee Yeun, Licznerski Pawel, Alavian Kambiz N, Simeone Antonio, Lin Zhicheng, Martin Eden, Vance Jeffery, Isacson Ole

Abstract excerpt

Two adjacent groups of midbrain dopaminergic neurons, A9 (substantia nigra pars compacta) and A10 (ventral tegmental area), have distinct projections and exhibit differential vulnerability in Parkinson's disease. Little is known about transcription factors that influence midbrain dopaminergic subgroup phenotypes or their potential role in disease. Here, we demonstrate elevated expression of the transcription...

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Identifiers

PMID: 20573704
DOI: 10.1093/brain/awq142
PMCID: PMC2892944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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