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Article

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.

Aging cell - 1 Oct 2010

Jazwinski S Michal, Kim Sangkyu, Dai Jianliang, Li Li, Bi Xiuhua, Jiang James C, Arnold Jonathan, Batzer Mark A, Walker Jerilyn A, Welsh David A, Lefante Christina M, Volaufova Julia, Myers Leann, Su L Joseph, Hausman Dorothy B, Miceli Michael V, Ravussin Eric, Poon Leonard W, Cherry Katie E, Welsch Michael A

Abstract excerpt

The search for longevity-determining genes in human has largely neglected the operation of genetic interactions. We have identified a novel combination of common variants of three genes that has a marked association with human lifespan and healthy aging. Subjects were recruited and stratified acc...

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Identifiers

PMID: 20569235
DOI: 10.1111/j.1474-9726.2010.00600.x
PMCID: PMC2941558

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20569235-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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